Indapril(Indapamide & Perindopril)

Therapeutic Group: Cardiovascular

Presentation

Indapril 2: Each tablet contains 0.625 mg of Indapamide and 2 mg of Perindopril Erbumine.

Indapril 4: Each tablet contains 1.25 mg of Indapamide and 4 mg of Perindopril Erbumine.

Description

Indapril, a fixed combination of an ACE inhibitor and a thiazide-like diuretic, leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately. In addition to those due to the additive synergistic action of the two constituents, when combined, it shows beneficial effects on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.

Indications

Essential hypertension.

Dosage & Administration

One tablet daily, preferably to be taken in the morning and before a meal.
Elderly patients: Normal dosage.
Renal failure: Creatinine clearance (CrCl) >30 ml/min: no dosage modification.
CrCl <30 ml/min: treatment contraindicated.

Side Effects

Asthenia, dizziness, headache, mood swings and/or sleep disturbances, cramps, hypotension, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, dry mouth, risk of dehydration in the elderly and in patients suffering from heart failure; changes in blood test results may occur.

Precautions

Disorders of electrolyte balance, diabetes, gout, hypotension, or strict sodium-free diets, heart or renal failure, atherosclerosis, renal artery stenosis, elderly.