Adora(Cefadroxil)

Therapeutic Group: Anti Bacterial

Presentation

Adora 500 Capsule: Each capsule contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 500 mg.

Adora Powder for Suspension: When reconstituted each 5 ml of suspension contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.

Adora Powder for Paediatric Drops: When reconstituted each 1.25 ml contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.

Description

Adora (Cefadroxil Monohydrate) is an acid-stable semi-synthetic oral antibiotic in the cephalosporin family of drugs. Cefadroxil acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation cephalosporins.

Indications

Adora (Cefadroxil Monohydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

*Upper respiratory tract infections caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci) and Streptococcus pneumoniae.

* Urinary tract infections caused by E. coli, Proteus mirabilis, and Klebsiella species.

* Skin and soft tissue infections caused by Staphylococci (including penicillinase producing strains) and Streptococci.



Dosage & Administration

The bioavailability and consequent chemotherapeutic effects of Cefadroxil are unaffected by foods. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

IndicationAdult (dose)Children (Dose)
Upper respiratory tract Infections1 gm per day in single (q.d.) or divided doses (b.i.d.) for 10 days 12 hourly30 mg/kg/day in a single or in equally divided doses every 12 hours
Urinary Tract Infections1 or 2 gm per day in single (q.d.) or divided doses (b.i.d.)30 mg/kg/day in equally divided doses every 12 hours
For all other UTIs 2 gm per day in divided doses (b.i.d)30 mg/kg/day in equally divided doses every 12 hours
Skin & soft tissue Infections1 gm per day in single (q.d.) or divided doses (b.i.d.)30 mg/kg/day in equally divided doses every 12 hours
Prophylaxis against bacterial endocarditis2 gm 1 hour prior to the procedure50 mg/kg 1 hour prior to the procedure

Side Effects

Generally cefadroxil is well tolerated. However, the most commonly reported side effects are gastrointestinal disturbances and hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.

Precautions

N/A

Use in Pregnancy & Lactation

Cefadroxil (Adora) is widely used as a first-line oral antibiotic for the treatment of uncomplicated urinary tract infections in pregnant women.